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This book introduces readers to the fascinating interaction of specialized gamete cells, forming the early embryo and a blueprint of new life. Readers will gain a thorough understanding of the complex physiological events and mechanical processes - such as ionic regulation, metabolism and intracellular signalling - to decipher cause and effect in fertilization. Wide-ranging in its approach, this book describes fertilization as a highly conserved mechanism throughout the animal kingdom, taking case studies from echinoderms, ascidians, amphibians and mammals through to other phyla. An excellent companion to undergraduate and postgraduate students of medicine, veterinary and biological sciences, this text provides an underpinning of the mechanisms of fertilization that inform assisted reproduction practice and research in medicine and agriculture. Explores the detailed phases before fertilization: the oocyte as a quiescent cell, attracting its partner gamete, followed by a cascade of pre-determined physiological events, to form the dynamic zygote cell; setting the scene for the early embryo, and beyond.

Fertilization (Biology) --- Germ cells. --- Gametogenesis.

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This comprehensively updated and expanded second edition builds on its successful and popular predecessor, retaining the practical features which made the first edition such an essential guide to IVF. The edition describes additions to the range of ART clinical treatments, including the use of testicular and epididymal sperm, blastocyst stage transfer, and new perspectives in cryobiology and cryopreservation techniques. By incorporating laboratory techniques and protocols, with an even greater emphasis on quality control, it provides an indispensable and practical account. The introductory chapters covering the scientific background that underpins effective laboratory practice have been substantially expanded, derived from research in mammalian systems into the molecular biology of oogenesis, oocyte maturation, and early embryo metabolism. This second edition distils a wealth of practical and scientific detail for the benefit of all IVF practitioners.

Fertilization in vitro, Human. --- Babies, Test tube --- Human fertilization in vitro --- Human in vitro fertilization --- Test tube babies --- Conception --- Human reproductive technology --- Fertilization in vitro --- Fetal Development. --- Germ Cells --- methods. --- growth & development.

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This extensively updated new edition provides an indispensable account of modern in-vitro fertilization practice, building upon the popularity of previous editions. The authors initially give a comprehensive review of the biology of human gametes and embryos, before outlining basic to advanced IVF techniques. New developments in practical techniques and understanding are discussed, including in-vitro maturation, vitrification, preservation of fertility for cancer patients, stem cell technology, preimplantation genetic testing, and the role of epigenetics and imprinting. The revised introduction also incorporates a 'refresher' study review of fundamental principles of cell and molecular biology, now updated with current knowledge of meiosis in human oocytes, embryo metabolism and basic principles of genome editing. With high-quality illustrations and extensive, up-to-date reading lists, it is a must-have textbook for trainee and practising embryologists, as well as clinicians who are interested in the scientific principles that underpin successful IVF.

Fertilization in vitro, Human.